Midterm Essay Example | Topics and Well Written Essays - 500 words - 11

Midterm - Essay Example Additionally, porosity allows waste products out of the scaffold. Biodegradability: Since the intention of TE is to facilitate the body’s own cells to eventually replace the implanted tissue engineered construct over time, scaffold are not intended to be permanent implants. Thus scaffold need to be biodegradable to allow cells to generate their own extra-cellular matrix (Robert, 2013). The key consideration should be the source of the cells. Cells are categorized by their sources. For instance, autologous cells are obtained from the same individual to which they need to be re-implanted; Allogenic cells are got from the body of the donor of the same species while xenogenic cells are from individuals of another species (Robert, 2013). During cells selection, cells leading to fewest problems with rejection and pathogen transmission are preferred (mostly autologous). However, autologous cells cannot be obtained if the individual affected is elderly or has suffered severe burns. Biocompatibility: The initial consideration of any biomaterial for TE is biocompatibility; cells must stick, function normally and move onto the surface and finally through the biomaterial and begin proliferation process before producing new matrix. Biomaterial construct must show negligible immune reaction after implantation to prevent rejection by the body Injectability: TE tissues requires precisely designed combination of cells and specialized scaffold support system, Injectable biomaterials, especially those delivered in aqueous solution are ideal delivery vehicles for both the cells and bioactive factors (Robert, 2013). c) When designing a template for repairing a damaged bone, I will ensure that the template is biodegradable, bioresorbable, three-dimensional; which provides mechanical strength to the bone while at the same time providing a guide for regeneration of bone tissue (Robert. 2013). Thus the template